But researchers have long suspected that to make a male, a second hormone must actively suppress the development of the female reproductive ducts, known as mullerian ducts.
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Lim-1 is also essential for the development of the female reproductive tract as it causes the persistence of the mullerian ducts that will eventually develop into the oviducts, uterus, cervix, and vagina.
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If a functional Y chromosome is present, the SRY gene will kick off a cascade that leads to the formation of testes, production of antimullerian hormone, and regression of the female internal organs ( Mullerian ducts ).
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If these cells can recognize testosterone, male development proceeds by prompting the female-forming structures, known as mullerian ducts, to degenerate and the male-forming structures, called wolffian ducts, to differentiate into the organs and ducts needed for male development.
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